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burden of hep d

Chronic hep delta infection is the most severe and rapidly progressive form of chronic viral hepatitis1,2

Hepatitis delta virus (HDV) can cause acute or chronic liver infection and an increased risk of hepatocellular carcinoma (HCC) or death2

Pie chart - up to 80% develop cirrhosis and liver failure

Up to 80% of chronic HDV 
patients in the US develop
cirrhosis and liver failure within 5-10 years1

15% develop these outcomes
within 1-2 years1

People with chronic hepatitis B face increased risk of death from cirrhosis and liver cancer, but those also infected with hep D have even greater risk3-5


Compared with HBV-monoinfected patients, patients also infected with hep delta have:



2 to 3 times more likely to develop cirrhosis. 3 to 6 times higher risk for hepatocellular carcinoma. 2 times more likely to develop hepatic decompensation. 2 to 3 times higher risk of death or liver transplantation.

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References: 1. Centers for Disease Control and Prevention. Hepatitis D questions and answers for health professionals. Updated March 9, 2020. Accessed August 9, 2021. https://www.cdc.gov/hepatitis/hdv/hdvfaq.htm 2. World Health Organization. Hepatitis D fact sheet. Updated July 28, 2021. Accessed August 9, 2021. https://www.who.int/news-room/fact-sheets/detail/hepatitis-d 3. Centers for Disease Control and Prevention. Hepatitis B questions and answers for the public. Updated July 28, 2020. Accessed August 9, 2021. www.cdc.gov/hepatitis/hbv/bfaq.htm 4. Da BL, et al. Gastroenterol Rep (Oxf.). 2019;7(4):231-245. doi:10.1093/gastro/goz023 5. Brancaccio G, et al. Aliment Pharmacol Ther. 2019;49:1071-1076. doi:10.1111/apt.15188